When Two-Factor Authentication is in place with other Apps that need to communicate with Zoho, Users will need to take staeps to establish that connection... click the link below to see a general knowledgbase articel on how to accomplish this with various Applications (including Zoho Apps/Google/Microsoft)

If connecting to Email in Zoho CRM... this App Password will be used when setting up your email credentials under Channels/Email in Zoho CRM